It's not more susceptible to issues with water. VX MileHigh gave you the best clue. Ethanol can be hard on fuel system parts. Injectors in particular can be harmed -- if not rated for Ethanol. And, it's not necessarily something that can/will happen in a few days/weeks.
I'm not sure what year you're reading from in the manual, but this may not be true for all 3 years. At one point (in that 99-01 range), I'm thinking compatibility with ethanol fuels became required. And, it would depend on the factory's use of viviton vs. rubber seals + the type of injector. Maybe fuel filter and/or fuel pump too?
With a company/manufacturer selling a vehicle with 100k/10yr warranty, they would want to take every precaution against fuel issues. (IMO) It may be there's no issue. This would be a good question for Jerry Lemond.
2001 Ebony VX and 1989 Custom 383 Corvette