Of course, 300 miles from a tank is possible. 22gal x 15mpg = 330miles -- if you ran it bone dry. With your typical 2 gals left, you're sitting right at 300 miles. For me, that's mostly city driving as I get right at 15mpg city.
On the opposite end, 19mpg would net 418 miles from a tank. If you jumped in, got on the hwy, and ran from a higher elevation to a lower elevation -- hwy only -- I bet it could be done. You'd probably have to stick with 60mph or just barely above that.
A strong tail wind could give you the same result.
I've seen a couple post 400 miles in a tank (in earlier years) but you have to remember 100% gasoline provides better results than that cheap-azz E10 they're ramming down our throats. (Plus, in the earlier days of the forum, the units had lower miles and were in better shape [on the average])
Because of the way the VX tank reads, it's hard to believe people run it empty enough to hit 400 miles anymore. Same goes true for 300 in the city. But, it's certainly possible.
If you're not getting close, pump your tires up to 35psi and make sure everything is tuned up (including clean injectors). You can get it.
(Caviat: high elevations)