I run fuel injector cleaner through mine regularly - actually a bit more often than just every oil change. I can't say I've noticed any changes that seem to be a direct result of it, but I haven't had any problems either, and for a couple of bucks every time, I figure why not. I do get better fuel economy than I used to (Joe will remember how fast I was going through it to and from Uwharrie). I'm not sure what to attribute that to, though. Maybe all I had was a temporary gas gauge glitch (sometimes it still reads lower than it should and then goes back up - on level ground too, I might add), or it could be the PCV replacement I did, or the change to a K&N filter, or fuel filter replacement, or fuel injector cleaner. Probably a bit of all of that.